No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression.
- Author:
Alessandro SERRETTI
1
;
Chiara FABBRI
;
Silvia PELLEGRINI
;
Stefano PORCELLI
;
Pierluigi POLITI
;
Silvio BELLINO
;
Marco MENCHETTI
;
Veronica MARIOTTI
;
Cristina DEMI
;
Valentina MARTINELLI
;
Marco CAPPUCCIATI
;
Paola BOZZATELLO
;
Elena BRIGNOLO
;
Paolo BRAMBILLA
;
Chi Un PAE
;
Matteo BALESTRIERI
;
Diana DE RONCHI
Author Information
1. Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. alessandro.serretti@unibo.it
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Antidepressants;
Psychotherapy;
5-HT;
5-HT1A receptor;
5-HT2A receptor;
Serotonin transporter;
COMT;
Genes;
Polymorphism;
Major depression
- MeSH:
Antidepressive Agents;
Counseling;
Depression;
Depressive Disorder, Major;
Genotype;
Humans;
Psychotherapy;
Receptor, Serotonin, 5-HT1A;
Receptor, Serotonin, 5-HT2A;
Serotonin;
Serotonin Plasma Membrane Transport Proteins
- From:Psychiatry Investigation
2013;10(2):180-189
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated. METHODS: One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417). RESULTS: IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome. CONCLUSION: Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
