Advances in the pathogenesis, prevention and treatment in necrotizing enterocolitis of newborn
10.3760/cma.j.issn.1673-4912.2012.03.037
- VernacularTitle:新生儿坏死性小肠结肠炎发病机制及防治研究进展
- Author:
Ruijuan WANG
;
Qiuping LI
- Publication Type:Journal Article
- Keywords:
Necrotizing enterocolitis;
Pathogenesis;
Inflammatory mediators;
Signal pathway;
Infant,newborn
- From:
Chinese Pediatric Emergency Medicine
2012;19(3):319-321
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis of newborn (NEC) remains a significant cause of morbidity and mortality in neonatal intensive care units.Although many advances have been made in the understanding of this disease,the pathophysiology remains incompletely clear,and treatment is mainly limited to supportive care.In recent years,studies have focussd on the role of the inflammatory mediators,signaling and their impacts on the disease process.Investigators also made some advances in the fields of intestinal proteome and probiotics.Early breasffeeding and probiotics are promoted to prevent and/or amehorate neonatal NEC.In this artical,we reviewed the advances in the above fields for helping to the pathogenesis and treatment of NEC.
