Low dose glucocorticoids for inhibiting radiological progression in rheumatoid arthritis: a systematic review
10.3760/cma.j.issn.1007-7480.2012.03.004
- VernacularTitle:小剂量糖皮质激素抑制类风湿关节炎放射学进展的系统评价
- Author:
Xinling WANG
;
Dong JIANG
;
Yuanwen JIANG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Glucocorticoids;
Radiology
- From:
Chinese Journal of Rheumatology
2012;16(3):156-161
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To evaluate the inhibitory effect of low dose glucocorticoid on progression of radiological damage in rheumatoid arthritis by systematic review.MethodsA search of MEDLINE (from 1966 to April 2010),Embase(from 1966 to April 2010),Cochrane Library(2 Issue,2010),CBM disc,CNKI,WANFANG and VIP Database was undertaken to collect randomized controlled trials published before April 2010 based on the Cochrane Collaboration recommendations.Additional reports were identified from the reference lists.Statistical analysis was performed with RevMan 5.0 software.ResultsEleven studies that met the inclusion criteria,in which 1395 patients,were included.Meta-analysis showed that the standardised mean difference in progression was 0.40 (95％CI 0.27～0.54 ) in favour of glucocorticoids over the first year.In studies that lasted for 2 years,the standardised mean difference in progression in favour of glucocorticoids at 1 year was -0.39[95％CI(-0.50～-0.27)] and was -0.73[95％CI(-1.29～-0.16)] at 2 years.All studies except one showed benefit of glucocorticoids treatment.ConclusionsThe results of this study has shown that low dose glucocorticoids can substantially reduce the progression rate of erosion in rheumatoid arthritis.
