Cardiac involvements in adult polymyositis or dermatomyositis: a qualitative systematic review
10.3760/cma.j.issn.1007-7480.2012.03.006
- VernacularTitle:成人多发性肌炎或皮肌炎心脏损害的系统性定性评价研究
- Author:
Lu ZHANG
;
Wei QIAO
;
Guochun WANG
- Publication Type:Journal Article
- Keywords:
Polymyositis;
Dermatomyositis;
Heart diseases;
Systematic review
- From:
Chinese Journal of Rheumatology
2012;16(3):167-172
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical features of cardiac involvement in polymyositis or dermatomyositis(PM/DM).MethodsAll articles published in Chinese and English were retrieved by searching the electronic resource databases.Theeligible articles that metthe predefined inclusion and exclusion criteria were included and then a systemic review was performed.ResultsTotally 23 articles were enrolled in this study,including 1452 patients.The incidence of cardiac involvement was 27.1％-85％.Heart failure was the most frequent (43.8％-76.9％) symptom.Among the abnormal ECG and UCG,the incidence of conduction abnormalities,left ventricular diastolic dysfunction andhyperkinetic left ventricular contraction 25％-38.5％,27.3％-51.5％ and 11.5％-42.3％ respectively.The pathological findings revealed myocardial inflamma-tion,degenerative changes and necrosis similar to those findings in skeletal muscles.Some patients'condition were improved aftergluco-corticoid stero and immunosuppressant treatment.Thirtypatients (30.9％) died as a direct result of heart disease.ConclusionHeart abnormalities are common in patients with PM/DM,most of them are subclinical,however.The efficacy of gluco corticoid steroid and immunosup-pressant treatment are uncertain.Cardiac involvement is a common cause of death.
