Significance of primary tumor volume on prognosis in nasopharyngeal carcinoma treated by Intensity-modulated radiotherapy
10.3760/cma.j.issn.1004-4221.2012.03.004
- VernacularTitle:调强放疗条件下鼻咽癌原发肿瘤体积对预后的影响
- Author:
Chuanben CHEN
;
Jianji PAN
;
Lisha CHEN
;
Penggang BAI
;
Shaojun LIN
;
Yu ZHANG
;
Xiuchun ZHANG
;
Zhaodong FEI
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms/intensity-modulated radiotherapy;
Planning target volume;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2012;21(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the correlation between primary tumor volume (PTV) and prognosis of nasopharyngeal carcinoma ( NPC ) treated by intensity-modulated radiotherapy ( IMRT ).Methods330 NPC patients treated by IMRT were included.Pretreatment computerized tomography image were input into tree-dimensional treatment-planning system,in which the primary tumor volume were calculated automatically.The receiver operating characteristic curve was used to determine the best cut-off point of PTV.Within the framework of UICC 2002 T stage,The PTV was divided into four groups:V1 ＜ 10cm3,V2 10-25 cm3,V3 ＞ 25-50 cm3 and V4 ＞ 50 cm3.Kaplan-Meier and Logrank test was used to analyze the survival,Cox proportion risk regression model were used to analysis the correlation between PTV and prognosis.ResultsThe mean PTV for all NPC patients was ( 34.2 ± 27.1 ) cm3 with the range of 0.4- 153.7 cm3.The 3-year overall survival for V1,V2,V3 and V4 stage were 88.6％,90.0％,91.2％ and 74.2％,respectively (x2 =12.83,P =0.005 ).There was no significant difference among V1,V2 and V3in terms of overall survival ( x2 =1.96,P =0.376).The 3-year distant metastasis-free survival and diseasesfree survival or overall survival were decrease in PTV ＞50 cm3 and PTV≤50 cm3 (77.4％:89.9％,x2 =7.24,P=0.007and 64.5％:85.1％,x2 =13.95,P=0.000 or 74.2％:90.3％,x2 =11.76,P=0.001).Multivariate analysis revealed that PTV was a adverse prognostic factors for overall survival (x2 =0.00,P =2.580).ConclusionOur data showed that the primary tumor volume had significantly impacted on the prognosis of NPC patients treated by intensity modulated radiotherapy.
