Effect of hemoperfusion therapy in children with acute tetramine poisoning
10.3760/cma.j.issn.1673-4912.2012.03.012
- VernacularTitle:血液灌流治疗儿童急性毒鼠强中毒的疗效观察
- Author:
Hongxiang GUO
;
Suqin ZHANG
;
Xinfang WANG
- Publication Type:Journal Article
- Keywords:
Tetramine;
Poisoning;
Blood perfusion;
Plasma concentration;
Children
- From:
Chinese Pediatric Emergency Medicine
2012;19(3):256-258
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the therapeutic experience and value of hemoperfusion in children with acute tetramine poisoning.MethodsAccording to the choice of children's legal guardian,67 cases with acute tetramine poisoning were divided into two groups:the perfusion group (48 cases),and the control group (19 cases).The patients in perfusion group received blood perfusion based on conventional treatment,while the patients in control group received conventional treatment only.Survival outcomes of patients with different serum tetramine concentrations in two groups were compared.ResultsWhen the serum concentration of tetramine was ＞0.5 mg/dl,patients in both groups died in a short time.When the serum concentration of tetramine was 0.20～0.49 mg/dl,the drop value of serum concentration of tetramine significantly greater in perfusion group [(0.28±0.02) mg/dl] than that in control group [(0.13±0.03) mg/dl] (P＜0.05).When the serum concentration of tetramine was ＜0.2 mg/dl,the drop value of serum concentration of tetramine in two groups showed no significant difference [ (0.12±0.02) mg/dl vs (0.11±0.03) mg/dl] (P＞0.05).Conclusion The treatment method for tetramine poisoning should be selected based on the serum concentration of tetramine.
