Effects of calcitriol, training on balance and lower extremity muscle strength on fall risk of postmenopausal osteoporotic women
10.3760/cma.j.issn.1674-0815.2012.03.006
- VernacularTitle:骨化三醇和平衡训练及肌力锻炼对绝经后骨质疏松女性跌倒风险的作用
- Author:
Hua LIN
;
Xiufen ZHU
;
Xin CHEN
;
Cheng QIAN
;
Lu FAN
;
Shushu HUANG
;
Changchang LIU
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Bone density;
Calcitriol;
Exercises;
Fall risk;
Education
- From:
Chinese Journal of Health Management
2012;06(3):162-165
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of caleitriol,training on balance and lower extremity muscle strength on fall risk of postmenopausal women with osleoporosis or osteopenia.Methods A total of 200 postmenopausal women with osteoporosis or osteopenia,whose balance test confirmed higher fall risk,were randondy assigned to group A or B.Those of group A received the following intervention:( 1 ) 0.25 μg calcitriol,QD; (2) general information on fall and osteoporosis; (3) balance training; (4) lower extremity muscle strength exercises.Those of group B were only treated with 0.25 μg calcitriol.All the participants were supplemented with 600 mg/d calcium and 125 IU/d vitamin D.Fall index,bone mineral density,serum levels of calcium and phosphorus,and adverse reactions were record.Results After 3 months' intervention,the fall index of both groups was significantly decreased ( group A:t =2.16,P＜0.05 ; group B:t =2.08,P＜0.05 ).After 6 months' intervention,the fall index of both groups went on decreasing,and significant difference of fall index between 6 month and baseline of group A and between group A and group B at 6 months was found.After 1-year intervention,the fall index of group A was further decreased in comparison with group B ( t =2.66,P＜0.05 ).No hypercalcemia occurred during the study period.Conclusion The fall risk of the patients with postmenopausal osteoporosis or osteopenia was reduced after 3 months' intervention.Twelve months' active vitamin D intervention could either reduce the risk of fall or improve bone mineral density.Patient education,balance training and muscle exercise may be effective intervention to reduce fall risk.
