Influence of Danshen injection on the serum levels of TNF-α, IL-6 in patients with acute pancreatitis
10.3760/cma.j.issn.1008-6706.2012.10.005
- VernacularTitle:丹参注射液对急性胰腺炎患者血清肿瘤坏死因子α、白细胞介素6水平的影响
- Author:
Xiuquan SHI
;
Peng GUO
;
Wenxuan LI
;
Zehao QIANG
;
Dayou SHEN
;
Naichang Lü
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Danshen injection;
Tumor necrosis factor α;
Interleukin 6
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(10):1449-1450
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the influence of Danshen injection on the serum levels of TNF-α,IL-6 in patients with acute pancreatitis(AP).Methods70 patients with AP were randomly divided into the experimental and control group.The two groups were given conventional anti-inflammatory,antisecretory,antispasmodic,inhibition of pancreatic secretion treatment,and the experimental group were treated with Danshen injection.Before trealment and 1,2,4,6 days after treatment,the serum TNF-α,IL-6 levels were measured in both groups.The time of blood and urine amylase(AMS) returned to normal was observed in both groups.Results2,4,6d after treatment,the serum TNF-α,IL-6 of the observation group were lower than that of the control group( all P ＜ 0.05 ) ;The blood AMS recovery time of the observation group was ( 2.55 ± 0.71 ) d,which had no significant difference with that of the control group(2.46 +0.82)d(t =0.32,P ＞0.05 ),while urinary AMS recovery time of the observation group was (4.30 ±0.72 ) d,which was shorter than that of the control group ( 6.84 ± 0.88 ) d ( t =0.02,P ＜ 0.05 ).ConclusionDanshen injection could reduce the serum TNF-α,IL-6 levels in patients with AP,and had no effect on the serum amylase,with the trend of faster lower urinary amylase.
