The comparison of the efficacy and safety of methylprednisolone and prednisone in the treatment of nephrotic syndrome complicated with hepatitis B
10.3760/cma.j.issn.1008-6706.2012.10.017
- VernacularTitle:甲泼尼龙与泼尼松治疗肾病综合征合并乙型肝炎的疗效及安全性比较
- Author:
Jing WANG
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Hepatitis B;
Liver damage;
Methylprednisolone;
Prednisone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(10):1472-1473
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the clinical efficacy and side effects of liver damage of the methylprednisolone (methylprednisolone tablets ) and prednisone treating nephrotic syndrome compicated with hepatitis B.Methods66 patients with nephrotic syndrome complicated with hepatitis B were randomly divided into control group and observation group,and each group had 33 cases.The control group was given prednisone in the morning,while the observation group was received methylprednisolone.The clinical efficacy and side effects of liver damage were compared between the two groups.ResultsAfter the treatment,the biochemical index significantly improved compared with the pre-treatment( all P ＜ 0.05 ) ;The total effective rate of observation group was 93.94％ higher than 84.85％ of the control group( x2 =1.44,P ＞ 0.05 ).However,there was no significant difference between the two groups( P ＞0.05) ;The observation group was significantly higher than the control group in negative rate of HBV-DNA (x2 =4.69,P ＜ 0.05 ) ;The side effects of liver damage in the observation group were lower than the control group (t =5.62,5.13,P ＜ 0.05 ).ConclusionMethylprednisolone and prednisone for treating patients with nephrotic syndrome compicated with hepatitis B had good clinical efficacy,and methylprednisolone was more effective than prednisone,especially it had less side effects of liver damage than prednisone.
