Clinical efficacy of treating pains suffered from metastatic bone cancer with composite kushen injection and pamidronate disodium injection
10.3760/cma.j.issn.1008-6315.2012.06.007
- VernacularTitle:复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛的效果观察
- Author:
Jinke YE
;
Yacong WU
;
Jing FU
;
Ling REN
;
Shouxi HU
- Publication Type:Journal Article
- Keywords:
Kushen injection;
Pamidronate disodium;
Malignant tumour;
Bone matstatic;
Pain
- From:
Clinical Medicine of China
2012;28(6):579-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of treating pains suffered from metastatic bone cancer with composite kushen injection and pamidronate disodium injection.Methods The clinical information of 60 cases of metastatic bone cancer patients suffered with pains was collected retrospectively.Thirty patients were assigned to the treatment group and 30 to the control group according to the treatment they underwent.The control group were treated with pamidronate disodium injection for 3 cycle,the treatment group were additionaly treated with composite kushen injection.The differences of two groups cases were compared in respect of the relief of pains and the changes of performance status (PS) and the incidence of adverse effects after treatment for 3 cycles.Results The objective remission rate of bone pain was 60.0％ (18/30) in the treatment group,which was significantly higher than that of 30.0％ (9/30) in the control group was higher( x2 =5.455,P=0.020 ).The incidence of adverse effect was 40.0％ (12/30) in the treatment group and 46.6％ (14/30) in the control group,with no significant difference between the two groups( x2 =0.271,P =0.602).In the treatment group the performance status of patients was( 2.30 ± 0.70 ) after treatment,which was better than that of( 1.80 ± 0.80 )before treatment(t =15.000,P =0.042),wheras there was no significant difference on performance status in the control group.Conclusion Kushen injection has synergistic effect with pamidronate disodium injection in treating pains with matstatic bone cancer.It could improve the short term efficacy,and significantly relief the pain and improve the quality of life.
