The effect of LMWH on Oligohydramnios at mid and late trimester of pregnancy

VernacularTitle:低分子肝素在妊娠中晚期羊水过少治疗中的应用
Author: Peiyu LIU
Publication Type:Journal Article
Keywords: Oligohydramnios; LMWH
From: Chinese Journal of Primary Medicine and Pharmacy 2012;(8):1163-1164
CountryChina
Language:Chinese
Abstract: ObjectiveTo detect the effect of LMWH on Oligohydramnios at mid and late trimester of pregnancy.MethodsPatients were divided into two groups.Control group was given Compound amino acids 500ml,5％glucose solution 500ml by intravenous infusion and water 1000ml per oral per day,and rest in bed with left lateral position for 10 days.Test group was given the same treatments as control group,plus Flagmin 5000U by subcutaneous injection per day.Amniotic fluid index was retest after treatment.Delivery mode,newborn birth weight,neonatal asphyxia and amount of postpartum hemorrhage were compared between two groups.ResultsAmniotic fluid index and newborn birth weight of test group was significantly higher than control group( P ＜ 0.05).Cesarean section rate,mild neonatal asphyxia rate was significantly lower than control group( P ＜ 0.05).Severe neonatal asphyxia rate and amount of postpartum hemorrhage had no significant differences (all P＞0.05).ConclusionLMWH treatment could increase amniotic fluid volume and newborn birth weight on Oligohydramnios at mid and late trimester of pregnancy,improve pregnancy outcome,without increase of postpartum hemorrhage.