Relationship between Dendritic cell, Interleukin-23 and Ulcerative Colitis
10.3760/cma.j.issn.1008-6315.2012.06.025
- VernacularTitle:树突状细胞和白细胞介素23与溃疡性结肠炎的关系
- Author:
Yong JIANG
;
Zongshun Lü
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Irritable bowel syndrome;
Dendritic cell;
Interleukin-23;
Immunohistochemistry
- From:
Clinical Medicine of China
2012;28(6):630-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the levels of S100+ DC,CD83 + DC and IL-23P19 between the patients with mucosa of ulcerative colitis ( UC ) and those with irritable bowel syndrome ( 0BS ).Methods Paraffin-embedded colon tissue from colonoscopic biopsy was detected in sixty UC and sixty IBS cases for the positivity of SI00 + DC,CD83 + DC and IL-23P19 using immunohistochemical SP method.Results There was no significant difference in the positive rates of S100 + DC and CD83 + DC between the two groups ( P ＞ 0.05 ),while significant difference in IL-23P19 level was found between the two groups( 85.0％ vs.70.0％ ; x2 =3.87,P ＜0.05 ).The infiltration densities of S100 + DC,CD83 + DC and expression of IL-23 P19 in the mild and severe UC patients were 24.43 ± 8.26/mm2,5.23 ± 1.66/mm2,95.03 ± 18.39/mm2,and 36.13 ± 11.36/mm2,10.13 ±3.29/mm2,133.38 ± 25.32/mm2,respectively.The difference between the mild and severe UC patients was significant ( P ＜ 0.05 ).No significant difference was found regarding the above three parameters between severity-stratified subgroups of the UC patients ( P ＞ 0.05 ).Conclusion In UC colon tissues,the infiltration density and activity of DC were increased.IL-23P19 level was elevated.The levels of S100 + DC,CD83 + DC and IL-23P19 were increased with the advancement of UC disease.
