Micafungin in the management of invasive fungal infections after liver transplantation
10.3760/cma.j.issn.1007-8118.2012.05.004
- VernacularTitle:米卡芬净治疗肝移植患者侵袭性真菌感染的应用研究
- Author:
Nan JIANG
;
Genshu WANG
;
Hua LI
;
Jian ZHANG
;
Binsheng FU
;
Guoying WANG
;
Yang YANG
;
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Fungal infection;
Micafungin
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(5):330-333
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the role of micafungin in the treatment of invasive fungal infection after liver transplantation.MethodsWe retrospectively studied the clinical data of 32 patients who developed invasive fungal infection after liver transplantation treated in our center between December 2008 and June 2010.The therapeutic effect,adverse effect,and the blood concentration/dose ratio of tacrolimus (tacrolimus concentration per dose.kg-1) before and after micafungin treatment were analysed.ResultsThe curative rate was 93.7％.There were no obvious toxicity and sideeffect.The blood concentration/dose ratio in the triazoles treatment group [(1031± 634.2) ng·ml-1/mg · kg-1] was markably higher than the micafungin treatment group [(172.6±39.45) ng·ml-1/mg · kg-1] and the control group (ceasing antifungal agents) [(183.8±47.08) ng· ml-1/mg · kg-1] (P＜0.05).However,there was no significant difference in the blood concentration/dose ratio between the micafungin treatment group and the control group (P＞0.05).ConclusionsMicafungin did not significantly affect the blood concentration/dose ratio of tacrolimus,and effectively treated invasive fungal infection in patients after liver transplantation.
