A preoperative prognostic score model to predict recurrence of hepatocellular carcinoma following liver transplantation
10.3760/cma.j.issn.1007-8118.2012.05.003
- VernacularTitle:一种预测肝癌肝移植术后肿瘤复发的术前评分模型
- Author:
Guoying WANG
;
Hua LI
;
Qi ZHANG
;
Jian ZHANG
;
Nan JIANG
;
Genshu WANG
;
Yang YANG
;
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Hepatocellular carcinoma;
Prognosis;
Recurrence;
Disease-free survival
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(5):325-329
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo establish a prognostic score model based on preoperative neutrophillymphocyte ratio (NLR) to predict recurrence of hepatocellular carcinoma (HCC) following liver transplantation.MethodsThe clinical data of 76 HCC patients undergoing liver transplantation were retrospectively analyzed.An NLR≥2.5 was considered to be elevated.A preoperative recurrence score was established by using three preoperative factors which significantly increased the risk of tumour recurrence after liver transplantation on multivariate analysis,namely,vascular invasion,tumour number＞3,and NLR≥2.5.We then evaluated the scoring system in predicting tumour recurrence of HCC after liver transplantation.ResultsArea under the receiver operating characteristic curve of preoperative recurrence score was 0.758,with scores of 2 and 3 having hazard ratios of 10.038 and 59.773,respectively.All ten patients with a score of 3 developed tumour recurrence in less than 6 months.The 1-,3- and 5-year tumour-free survival rates for patients with a score of 0,1 and 2 were 95.0％,78.4％,and 78.4％ vs.76.9％,66.9％,and 63.2％ vs.51.9％,8.7％,and 8.7％,respectively.Of 55 patients who had no gross vascular invasion,5 patients with both tumour number＞3 and NLR≥2.5 developed recurrence in less than 31 months.ConclusionsPatients with both preoperative NLR≥2.5 and tumour number more than 3 were at a high risk of tumour recurrence after liver transplantation for HCC.The preoperative recurrence score model strongly correlated with tumour recurrence,and may aid in the selection of patients with HCC for liver transplantation.
