The effect of expressions of ERCC1on neoadjuvant chemotherapy and prognosis in advanced gastric cancer
10.3760/cma.j.issn.1007-631X.2012.05.003
- VernacularTitle:切除修复交叉互补基因1表达对进展期胃癌新辅助化疗及预后的影响
- Author:
Yanqiang SONG
;
Guiliang MA
;
Chao LIU
;
Lei MA
;
Weizheng MAO
;
Yang LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Gene expression;
Antineoplastic combined chemotherapy protocols;
Prognosis
- From:
Chinese Journal of General Surgery
2012;27(5):360-363
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate theeffectof expression of excision repair cross complementing 1(ERCC1) on adjuvant chemotherapy and prognnsis in advanced gastric cancer.MethodsIn this study 88 advanced gastric cancer cases were divided into initial neoadjuvant chemotherapy group (45 patients) and upfront surgical group (43 cases).In neoadjuvant chemotherapy group two courses neoadjuvant chemotherapy with XELOX were given before an interval standard radical gastrectomy.Postoperatively another four cycles of chemotherapy with XELOX were given; In upfront surgical group standard radical gastrectomy was done followed by 6 cycles of postoperative chemotherapy with XELOX;Patients in the two groups were followed up for 3 years.ResultsERCC1positive expression were 49％ and 44％ in neoadjuvant group and surgical patients; Response rate in neoadjuvant chemotherapy group was 49％.Patients with ERCClnegative expression were more sensitive to chemotherapy (P ＜0.05 ); 3-year recurrence-free survival rate in patients with ERCC1negative expression was 64％,which was significantly higher than 30％ in patients with positive expression,the difference was statistically significant (P ＜ 0.05 ) ;3-year recurrence-free survival rate in initial surgical group patients with ERCCl-negative expression was 79％,significantly higher than in patients with positive expression (38％),the difference was statistically significant (P ＜0.05) ; Cox regression analysis revealed that ERCC1expression is closely related to 3-year disease-free survival ( P ＜ 0.05 ). ConclusionsERCC1expression in patients with advanced gastric cancer is related to chemosensitivity and prognosis,it can forecast the prognosis and chemotherapy sensitivity.
