Study of periphery artery and renal injury in elderly patients with dipper and non-dipper isolated systolic hypertension
10.3760/cma.j.issn.0254-9026.2012.05.008
- VernacularTitle:老年人杓型与非杓型高血压对外周血管和肾脏的损害
- Author:
Gongxian YUAN
;
Hua WANG
;
Jianghua REN
;
Congxin HUANG
;
Yinghui WANG
;
Zhenli LIU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Arteriosclerosis;
Circadian rhythm;
Renal insufficiency,chronic
- From:
Chinese Journal of Geriatrics
2012;31(5):380-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate periphery artery and renal injury in elderly patients with dipper and non-dipper isolated systolic hypertension(ISH). Methods Totally 187 elderly cases were divided into 51 patients with non-dipper hypertension,70 patients with dipper hypertension aged (72.4±5.6) years and 66 cases with normal blood pressure as control according to results of dynamic blood pressure recorder. Ankle-brachial index (ABI),brachial ankle artery pulse wave velocity (baPWV),retinol-binding protein (RBP) and Cystatin C were assessed. ABI and baPWV were determined by a non-invasive automatic waveform analyzer. Results The baPWV value in nondipper group was higher than dipper group [(1869.3±285.6)cm/s vs.(1703.1±235.2)cm/s,q=4.73,P＜0.01],while the value of ABI in non-dipper group was lower than dipper group (1.0 ±0.2vs.1.1±0.2,q=4.74,P＜0.01).The level of Cystatin C was elevated in non-dipper group versus dipper group [(1.4±0.5) mg/L vs. (1.0±0.5)mg/L,q=6.92,P＜0.01]. There were no differences in RBP concentration among the three groups (F=2.39,P＞0.05).At baPWV＞ 1400cm/s,the level of Cystatin C was increased in 47 cases with non-dipper hypertension as compared with 64 cases with dipper hypertension [(1.4±0.5)mg/L vs.(1.1±0.5)mg/L,q=5.59,P＜0.01].Conclusions The elderly patients with non-dipper hypertension may be more easily suffered from periphery artery and renal injury in comparison with dipper hypertension.
