Correlation between connexin37 C1019T polymorphism and ischemic stroke and its outcome
10.3760/cma.j.issn.1673-4165.2012.04.003
- VernacularTitle:连接蛋白37基因C1019T多态性与缺血性卒中及其转归的相关性
- Author:
Dan LIU
;
Jiangong SUN
;
Hongying SUN
;
Guangwei ZHANG
;
Jia ZHANG
;
Guixi WANG
;
Jing YANG
;
Ruiqi SONG
- Publication Type:Journal Article
- Keywords:
Connexins;
Polymorphism,Genetic;
Stroke;
Brain Ischemia
- From:
International Journal of Cerebrovascular Diseases
2012;20(4):251-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between cornexin37 (Cx37) CI019T polymorphism and ischemic stroke and its outcome.Methods Restriction fragment length polymorphism analysis was used to detect the distribution of Cx37 C1019T polymorphism in a ischemic stroke group and a control group.The modified Rankin scale (mRS) was used to evaluate the neurological outcome at 3 months after onset.Results A total of 235 patients in the control group,and 232 patients in the ischemic stroke goup were recruited.In the ischemic stroke group,210 had a good outcome (mRS ＜3) and 22 had a poor outcome (mRS≥ 3).The TT genotype (12.93％ vs.6.39％ ; x2 =10.087,P =0.006) and T allele (31.25％ vs.21.49％ ; x2 =11.466,P=0.001) frequency in the ischemic stroke group were significantly higher than those in the control group.Multivariatelogistic regression analysis showed that TT genotype (odds ratio [OR] 5.794; 95％ confidence interval [CI] 1.405-23.894; P =0.015) and T allele (OR 131.016,95％ CI 6.943 -2 472.477; P =0.001)signifkantly increased the risk of ischemic stroke.Univariate analysis showed that TT genotype (OR 0.650,95％ CI 0.144 - 2,934; P =0.575),CT genotype (OR 0.622,95％ CI 0.234 - 1.655; P =0.342),and CC genotype (OR 0.654,95％ CI 0.268 - 1.595; P =0.350) had no significant correlation with the outcome of ischemic stroke.Conclusions Cx37 1019TT genotype and T allele may increase the risk of ischemic stroke.T allele is one of genetic susceptibility factors for ischemic stroke; however,its gene polymorphism is not associated with the outcome of ischemic stroke at 3 months after onset.
