Low flow shear stress and atherosclerosis
10.3760/cma.j.issn.1673-4165.2012.04.013
- VernacularTitle:血流低切应力与动脉粥样硬化
- Author:
Yan PI
;
Lili ZHANG
;
Jingcheng LI
- Publication Type:Journal Article
- Keywords:
Arteriosclerosis;
Shear Strength;
Stress,Mechanical;
Endothelium,Vascular;
Blood Vessels;
Signal.Transduction
- From:
International Journal of Cerebrovascular Diseases
2012;20(4):305-309
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is the important pathologic basis of coronary artery disease,cerebrovascular disease,peripheral arterial disease and other vascular diseases.Studies have shown that the atheromatous plaques occur mainly in regions of curvature,bifurcation,and branching of the artery,indicating that low flow shear stress is closely associated with the occurrence of atherosclerosis.Low flow shear stress involves in the induction of atherosclerosis through acting on mechanosensitive molecules in endothelial cell that transduce mechanical stimuli into chemical signals,activate the corresponding intracellular signaling pathways.This article reviews the relationship between low flow shear stress and atherosclerosis.
