The roles of hypoxia inducible factor-1 in apoptosis after cerebral ischemia
10.3760/cma.j.issn.1673-4165.2012.04.015
- VernacularTitle:缺氧诱导因子-1在脑缺血后细胞凋亡中的作用
- Author:
Junxia LIU
;
Yongjie LUO
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor 1;
Brain ischemia;
Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2012;20(4):315-320
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1 (HIF-1) is an inportant regulatory factor in adapting to hypoxia in the hypoxic environment for cells.The changes of the numbers of HIF-1 in cells may regulate hypoxia-responsive gene transcription.HIF-1 may inhibit neuronal apoptosis and thus play a ncuroptotective role,and may also show a neurotoxic effect by inducing neuronal apoptosis.
