Clinical efficacy of 0.1％ tacrolimus ointment combined with paroxetine for the treatment of neurodermatitis
10.3760/cma.j.issn.0412-4030.2012.05.010
- VernacularTitle:0.1％他克莫司软膏联合帕罗西汀治疗神经性皮炎的疗效观察
- Author:
Yingqiu BAO
;
Wen SU
;
Yu FU
- Publication Type:Journal Article
- Keywords:
Neurodermatitis;
Sleep initiation and maintenance disorders;
Tacrolimus ointment;
Antianxiety agents
- From:
Chinese Journal of Dermatology
2012;45(5):333-336
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the clinical efficiency of 0.1％ tacrolimus ointment combined with paroxetine in patients with neurodermatitis associated with insomnia.MethodsTotally,74 patients suffering from neurodermatitis and insomnia were consecutively enrolled in this study,and randomly assigned into the combination group and control group according to their number(odd or even).Both groups were given topical 0.1％ tacrolimus ointment twice a day,and the combination group was additionally given oral paroxetine 10 mg once a day,for 8 weeks.The outcome parameters included main symptoms of neurodermatitis and Pittsburgh sleep quality index(PSQI) score.ResultsNo significant difference was observed in the cure rate (54.3％(19/35) vs.53.1％ (17/32),P＞ 0.05) or response rate (82.9％ (29/35) vs.81.3％ (26/32),P＞ 0.05),between the combination group and control group.PSQI score was significantly lower in the combination group than in the control group after 8 weeks of treatment(P ＜ 0.05).ConclusionsThe 0.1％ tacrolimus ointment can be used to treat neurodermatitis safely.Antianxiety treatment can reduce the recurrence of neurodermatitis associated with insomnia,and improve the quality of sleep in patients.
