Lung Transplantation for Chronic Humidifier Disinfectant-Associated Lung Injury.
10.4266/kjccm.2016.31.2.146
- Author:
Won Young KIM
;
So Woon KIM
;
Kyung Wook JO
;
Sae Hoon CHOI
;
Hyung Ryul KIM
;
Yong Hee KIM
;
Dong Kwan KIM
;
Seung Il PARK
;
Sang Bum HONG
- Publication Type:Case Report
- Keywords:
disinfectants;
humidifiers;
inhalation exposure;
lung transplantation;
oxygen inhalation therapy
- MeSH:
Adult;
Catheters;
Disinfectants;
Extracorporeal Membrane Oxygenation;
Female;
Fibrosis;
Humans;
Humidifiers*;
Inhalation;
Inhalation Exposure;
Intensive Care Units;
Korea;
Lung Injury*;
Lung Transplantation*;
Lung*;
Oxygen Inhalation Therapy;
Respiration, Artificial;
Survivors
- From:Korean Journal of Critical Care Medicine
2016;31(2):146-151
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the spring of 2011, a cluster of lung injuries caused by humidifier disinfectant (HD) usage were reported in Korea. Many patients required mechanical ventilation, extracorporeal membrane oxygenation, and even lung transplantation (LTPL). However, the long-term course of HD-associated lung injury remains unclear because the majority of survivors recovered normal lung function. Here we report a 33-year-old woman who underwent LTPL approximately four years after severe HD-associated lung injury. The patient was initially admitted to the intensive care unit and was supported by a high-flow nasal cannula. Although she had been discharged, she was recurrently admitted to our hospital due to progressive lung fibrosis and a persistent decline in lung function. Finally, sequential double LTPL was successfully performed, and the patient's clinical and radiological findings showed significant improvement. Therefore, we conclude that LTPL can be a therapeutic option for patients with chronic inhalation injury.
