A proton magnetic resonance spectroscopy imaging study on prefrontal lobe and hippocampus in male patients with first-episode mania
10.3760/cma.j.issn.1674-6554.2012.04.014
- VernacularTitle:首发男性双相障碍Ⅰ型躁狂发作患者额叶白质和海马氢质子波谱研究
- Author:
Liqian CUI
;
Lijun JIANG
;
Wei DENG
;
Chaohua HUANG
;
Zhuangfei CHEN
;
Mingli LI
;
Qiang WANG
;
Yingcheng WANG
;
Xiaohong MA
;
Qiyong GONG
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Frontal lobe;
Hippocampus;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(4):330-332
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo identify the metabolic alterations on prefrontal lobes and hippocampus in male patients with the first-episode mania using proton magnetic resonance spectroscopy(H-MRS).Method 18 male patients with the first-episode mania and 27 healthy subjects matched for age,gender,and years of education were included in the study.1 H-MRS was performed in two sides of the hippocampus and frontal lobes regions.The ratios of N-acetylaspartate (NAA),choline (Cho) to creatine (Cr) were measured.One-sample t test and paired-samples t test were used for statistic process.ResultsMale patients with the first-episode mania presented decreased NAA/Cr in left frontal lobe and hippocampus regions when compared to normal controls( left frontal lobe (1.68 ±0.19 vs 1.86 ± 0.19),hippocampus ( 1.32 ± 0.10 vs 1.43 ± 0.16 ),P ＜ 0.01 ),but there were no significant difference in NAA/Cr for right frontal lobe and hippocampus regions between groups ( all P ＞ 0.05 ).Two groups also showcd no significant difference for Cho/Cr in bilateral frontal lobe and hippocampus (P ＞ 0.05 ).Conclusion There is significant difference of manifestation of 1H-MRS between male patients with mania and normal controls,which reflects neuronal dysfunction in the prefrontal lobes and hippocampus.
