Association study of disrupted-in-schizophrenia-1 gene single nucleotide polymorphism with schizophrenia in Han Chinese population
10.3760/cma.j.issn.1674-6554.2012.04.016
- VernacularTitle:偏执型精神分裂症患者精神分裂症断裂基因1单核苷酸多态性研究
- Author:
Weiyun GUO
;
Wenqiang LI
;
Hongxing ZHANG
;
Wei HAO
;
Luxian LV
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Disrupted-in-schizophrenia-1;
Association;
Positive and negative syndrome scale
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(4):337-339
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the association between single nucleotide polymorphisms (SNPs) in DISC1 gene.MethodsThe studied sample consisted of 528 patients with schizophrenia (264 males and 264 females) and 528 healthy controls (264 males and 264 females).Two function SNPs were selected and gcnotyped by Illumina Golden Gate assay.Genotype and allele frequencies were compared between patients and controls to assess the association to schizophrenia.The clinical features of the hospital first patients were further examined with the Positive and Negative Syndrome Scale (PANSS) before trcatment with antipsychotics.ResultsTwo SNPs were genotyped in subjects.A significant association was found between rs3737597 and schizophrenia in genotype (387:133:8,350:164:14) and allele frequencies (907:149,864:192,P＜0.05 ).Moreover,the haplotypes,A-A constructed from two SNPs showed significant differences between cases and controls ( P＜ 0.05).For rs821616,there were significant difference in positive syndrome score,delusions and poor rapport between patients with genotypes AA or not.ConclusionThis study describes a positive association between DISC(1) and schizophrenia in the Han Chinese population and DISC1 is the susceptible gene in schiz ophrenia.
