Effects of intraabdominal administration of pseudomonas acerug vaccine on cytoimmunity in advanced gastric cancer patients
10.3760/cma.j.issn.1007-631X.2012.05.008
- VernacularTitle:铜绿假单胞菌制剂腹腔给药对进展期胃癌患者细胞免疫水平的影响
- Author:
Zhaoxu ZHENG
;
Qiang FENG
;
Quan XU
;
Yuquan XIE
;
Jianming LIANG
;
Xinghua YUAN
- Publication Type:Journal Article
- Keywords:
Vaccines
- From:
Chinese Journal of General Surgery
2012;27(5):377-380
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the safety and effects of pseudomonas aerug PA-MSHA vaccine on cytoimmunity in advanced gastric cancer patients. MethodsSeventy two patients with advanced gastric cancer were randomly divided into experimental group and control group. Tumor bed was treated intraoperatively by pseudomonas vaccine injection in experimental group.The venous bloods were sampled prior to surgery (preoperative) and on days 10,20,and 30 postoperatively.The total lymphocyte count and lymphocyte subpopulations were detected while the postoperative complications and adverse drug reaction were observed,prognosis was evaluated. ResultsThe total lymphocyte count(P =0.042) and the counts ofCD3+ lymphocyte(P =0.027) and NK cell increased (P =0.012) obviously in experimental group.CD8+ lymphocyte decreased(P =0.037),but the counts of CI4+ lymphocyte and CD4+/CD8+ were not significantly different.Complications were not significantly different in the two groups.One year survival rate was longer ( 94.9％ ) in experimental group than that in the control group ( 83.3％ ) ( P =0.022 ).ConclusionsPeritoneal cavity administration with pseudomonas aerug vaccine was safe,and effectively helps regulate cytoimmunity in postoperative patients of advanced gastric carcinoma.
