The change of T-lymphocyte subgroup in children with infectious mononucleosis
10.3760/cma.j.issn.1673-4912.2012.02.020
- VernacularTitle:儿童传染性单核细胞增多症T细胞亚群变化
- Author:
Suhong YANG
;
Junjie FENG
;
Aizhong MA
- Publication Type:Journal Article
- Keywords:
infectious mononucleosis;
T-lymphocyte subgroup;
CD4/CD8;
Children
- From:
Chinese Pediatric Emergency Medicine
2012;19(2):166-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of T-lymphocyte subgroup in children with infectious mononucleosis (IM).Methods Sixty young children with IM caused by Epstein-Barr virus (EBV) were recruited for this study in Jiaxing First Hospital from Jan 2005 to Dec 2010.Thirty-six normal children were chosen as control group.Both of the two groups were detected blood test,blood smear,T-lymphocyte subgroup ( including CD3,CD4,CD8,CD4/CD8 ),liver and kidney function test,IgM antibodies of EBV,cytomegalovirus,adenovirus,and hepatitis virus.Results Compared with the control group (53.58％ ± 5.97％,31.22％±8.72％ ),the ratio of CD3 (81.55％ ±9.04％ ) and CD8(58.13％ ± 13.35％ ) were significantly higher in IM group( P ＜0.05 ).And the ratio of CD4 ( 18.19％ ± 7.61％ ) and CD4/CD8 (0.37 ± 0.33) were significantly lower in IM group,compared with the control group (36.98％ ± 5.32％,1.98 ± 0.41 )(P ＜ 0.05 ).While the leukocyte count,the ratio of abnormal leukomonocyte,and alanine transaminase had no correlation with the decrease of CD4/CD8 ( P ＞ 0.05 ).Conclusion Children with IM caused by EBV have bad immunocompetence,and we can treat them with immunotherapy early.
