Detection of secondary infections of acute necrotizing pancreatitis: a comparison study of 99mTc-ciprofloxacin scintigraphy and CT
10.3760/cma.j.issn.1674-1935.2012.01.012
- VernacularTitle:99mTc-环丙沙星显像与CT检测急性坏死性胰腺炎继发感染的比较研究
- Author:
Jianhua WANG
;
Chengwei SHAO
;
Xiaodong LI
;
Jian ZHANG
;
Guixia PAN
;
Ye PENG
;
Juanli MAO
;
Jianming ZHENG
;
Changjing ZUO
;
Jianming TIAN
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Infection;
.Radionuclide imaging;
Ciprofloxacin;
X-ray computed tomography
- From:
Chinese Journal of Pancreatology
2012;12(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate 99mTc-ciprofloxacin (Infecton) scintigraphy as a method for detecting secondary infections associated with ANP in swine,in comparison with CT.MethodsTwenty-eight healthy swine were randomly assigned to control group (n =6),non-infected ANP (n =6) and infected ANP group( n =16).ANP model was induced by retrograde injection of sodium taurocholate and pancreatic protease mixture into the biliary and pancreatic duct.Two days after ANP induction,swine in infected ANP group were injected with 3 x 108 E.coli into pancreatic tissue,while swine in non-infected ANP group were injected with inactivated E.coli.At 7 d after inoculation,at 0.5,1,2,3,4,and 6 h after intravenous administration of 370 MBq of Infecton,SPECT scan was performed.Then 64-slice spiral CT scan was performed.Then swine were sacrificed,and histopathology examination and bacterial culture of pancreatic tissue were performed.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the two methods to detect secondary infections were determined.ResultsThere were no abnormality in the normal pancreas and the bacterial culture was negative.There were pancreatic necrosis in the non-infected ANP group,but the bacterial culture was negative.There were pancreatic necrosis and infection in the infected ANP group and the bacterial culture was positive.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the Infecton method were 93.8％ ( 15/16 ),91.7％ ( 11/12 ),92.9％ ( 26/28 ),93.8 ％(15/16) and 91.7％ ( 11/12),whereas these values for CT were 12.5％ (2/16),100.0％ ( 12/12),50.0％(14/28),100.0％ (2/2) and 46.2％ (12/26),respectively.The sensitivity,accuracy,and negative predictive value of the Infecton method were significantly higher than those in CT group (P ＜0.01 ).ConclusionsInfecton scintigraphy may be a better procedure for detecting ANP secondary infections than CT.
