A clinical evaluation of prognosis of severe brain injury using S100B protein
10.3760/cma.j.issn.1673-4904.2012.08.002
- VernacularTitle:脑损伤标志物S100B蛋白评价重型脑损伤预后的临床研究
- Author:
Jing YE
- Publication Type:Journal Article
- Keywords:
Brain injuries;
S100 proteins;
Prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(8):3-5
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the value of S100B protein in the evaluation of prognosis for patients with severe brain injury.MethodsThe serum S100B protein concentration was determined by enzyme-linked immunosorbent assay in 86 patients with severe brain injury(observation group) and 89 healthy individuals(control group) from February 2009 to March 2011.The clinical symptom and Glasgow outcome scale(GOS) score were measured.ResultsIn the 86 patients of observation group,33 patients were with good-recovery,25 patients were with moderate-deficit,14 patients were with severe-deficit,1 patient was detected of persistent vegetative status,and 13 patients died.The rate of excellent prognosis and worse prognosis were 67.4％ (58/86) and 32.6％ (28/86).The concentration of S100B protein was obviously higher in observation group [ ( 1.42 ± 0.42 ) μ g/L ] than that in control group [ (0.16 ± 0.05 ) μ g/L ] in 24 hours (P ＜ 0.01 ).The concentration of S100B protein in worse prognosis [ (2.15 ± 0.51 ) μ g/L] was obviously higher than that in excellent prognosis [ ( 0.92 ± 0.49) μ g/L ] ( P ＜ 0.05).ConclusionsS100B protein has high sensitivity and specificity to evaluate brain injury,and it is a reliable and valid biochemical marker of the brain damage.It has important clinical value in the evaluation of severity and prediction of prognosis for patients with severe brain injury.
