The correlation between the OATP1B1 521T ＞ C genetic polymorphism and essential hypertension
10.3760/cma.j.issn.1008-6706.2012.05.003
- VernacularTitle:有机阴离子转运多肽1B1521T＞C基因多态性与原发性高血压的相关性
- Author:
Lili YE
;
Jian QIU
;
Shujin ZHAO
;
Changjiang HONG
;
Fei XIAO
;
Yuhai ZOU
- Publication Type:Journal Article
- Keywords:
OATP1B1 521T ＞ C;
Gene;
Polymorphism;
Essential Hypertension
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(5):646-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the OATP1B1 521T ＞ C genetic polymorphism and essential hypertension.Methods 164 essential hypertension subjects and 159 normotensive subjects were detected by the TaqMan-MGB probe real-time fluorescence quantitative PCR,and the results were compared with those of DNA sequencing.Results The frequencies of T/C genotype and C allele of OATP1B1 521T ＞ C gene of the essential hypertension subjects were obviously lower than those of the normotensive subjects(T/C genotype:0.16 vs 0.25,P ＜0.05 ;C allele:0.10 vs 0.17,P ＜0.05),The difference was significant.Binary logistic stepwise regression analysis was used for evaluatine the risk factors of essential hypertension,there was significant relationship between OATP1 B1 52IT ＞ C gene polymorphism and essential hypertension.Conclusion The SLCO1 B1 521T ＞ C variant was common in Chinese essential hypertension population,but the difference of frequency of SLCO1B1 52IT ＞ Cmuton between the essential hypertension patients and the normotensive controls was of obviously statistical significance,which indicates that the SLCO1B1521T ＞ C variant maybe associate with essential hypertension.
