Research on the relationship between the expression of estrogen receptor, progesterone receptor and epidermal growth factor receptor in uterine leiomyoma and the recurrence after myomectomy
10.3760/cma.j.issn.1673-4904.2012.06.010
- VernacularTitle:雌、孕激素受体及表皮生长因子受体表达与子宫肌瘤术后复发的相关性研究
- Author:
Xiaoping NI
;
Lihong LEI
;
Liyan LI
- Publication Type:Journal Article
- Keywords:
Receptors,estrogen;
Receptors,progesterone;
Receptor,epidermal growth factor;
Recurrence;
Uterine leiomyoma
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(6):25-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of estrogen receptor (ER),progesterone receptor(PR)and epidermal growth factor receptor(EGFR)in uterine leiomyoma and the recurrence after myomectomy.Methods Eighty cases underwent myomectomy were enrolled in this study.ER,PR and EGFR expression in uterine leiomyoma tissue and normal myometrium tissue were examined by immunohistochemical technique.All the patients were followed up regularly after myomectomy.Results The positive expression rate of ER,PR and EGFR in uterine leiomyoma tissue were significantly higher than those in normal myometrium tissue[88.8％(71/80)vs.48.8％(39/80),92.5％(74/80)vs.30.0％ (24/80),86.2％(69/80)vs.57.5％(46/80),P ＜ 0.05].The recurrence rates in ER,PR and EGFR positive expression patients were significantly higher than those in negative expression patients[42.3％(30/71)vs.22.2％(2/9),41.9％(31/74)vs.16.7％(1/6),42.0％(29/69)vs.27.3％(3/11),P ＜ 0.05].The recurrence times in ER,PR and EGFR positive expression patients were significantly shorter than those in negative expression patients(P ＜0.05).The expression of EGFR had positive correlation with ER and PR(r =0.837,0.702,P ＜ 0.05).Conclusions The recurrence of uterine leiomyoma may have correlation with high expression of ER,PR and EGFR in uterine leiomyoma.
