Cinical observation of insulin detemir combined with acarbose in curing type 2 diabetic patients
10.3760/cma.j.issn.1008-6706.2012.06.023
- VernacularTitle:地特胰岛素联合阿卡波糖治疗2型糖尿病临床观察
- Author:
Danhua LAO
;
Jianxian HUANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Insulin;
Acarbose
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(6):846-848
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of insulin detemir combined with acarbose in treatment of patients with type 2 diabetes (T2DM).Methods32 T2DM patients whose blood glucose control was poor receiving twice daily isophane protamine biosynthetic human insulin( Novolin 30R) combined or not combined with oral hypoglycemic drugs,were switched to receive insulin detemir injection once daily and oral acarbose three times daily for 12 weeks.By self-contrasted method,observed blood glucose before and after three meals,before sleeping,glycated hemoglobin ( HbA1c),change of body mass index( BMI),incidence of hypoglycemia,compliance and satisfaction of patients (by questionnaire) before and after treatment.ResultsAfter treatment,the blood glucose before and after three meals,before sleeping and HbA1 c declined sigmifieatly ( t =11.212,14.997,10.863,17.950,11.108,14.034,12.422,22.764,all P ＜0.01 )compared to state before treatment.The rate of hypoglycemia in the day was 3.1％,without nocturnal symptoms of hypoglycemia.BMI had certain declining,but there was no statistical significance (P ＞ 0.05).The compliance and satisfaction of patients were in a higher rate (x2 =10.255,9.143,all P ＜ 0.01 ).ConclusionInsulin detemir combined with acarbose could effectively control the blood glucose,incidence of hypoglycemia,without increasing body mass,achieve good compliance and satisfaction of patients.
