Clinical study of applying low molecular weight heparin calcium in different periods of reteplase for acute myocardial infarction
10.3760/cma.j.issn.1673-4904.2012.06.002
- VernacularTitle:不同时段应用低分子量肝素钙在瑞替普酶治疗急性心肌梗死中的临床研究
- Author:
Suchun XIONG
;
Wenhu LI
;
Qiulan GUO
;
Yichu CHEN
;
Ganhai CHEN
;
Wenping HUANG
- Publication Type:Journal Article
- Keywords:
Heparin,low-molecular-weight;
Myocardial infarction;
Reteplase;
Intravenous thrombolysis
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(6):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of applying low molecular weight heparin calcium in different periods of reteplase for acute myocardial infarction(AMI).Methods Ninety-one cases of AMI were divided into group A(30 cases),group B(30 cases)and group C(31 cases)by random digits table.The patients in three groups were given reteplase intravenous thrombolysis,and 5000 U low molecular weight heparin calcium was abdominal wall subcutaneous injections once 12 h at intravenous thrombolysis immediately(group A),after intravenous thrombolysis 6 h(group B)and 12 h(group C).They all were treated for 7-10 d.The rate of coronary artery recanalization,acute phase complication and adverse reaction were compared among three groups.Results The rate of coronary artery recanalization in group A,B and C was 76.7％(23/30),96.7％(29/30),74.2％(23/31)respectively.The rate of coronary artery recanalization in group B was significantly higher than that in group A and C(P ＜ 0.05).The rate of acute phase complication and adverse reaction in group B[33.3％(10/30)]was significantly lower than that in group A and C[70.0％ (21/30)and 61.3％(19/31)](P ＜ 0.05).Conclusions After reteplase intravenous thrombolysis in 6 h,applying low molecular weight heparin calcium can significantly improve the rate of coronary artery recanalization and reduce the rate of acute phase complication and adverse reaction.
