MiRNA and non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2012.04.013
- VernacularTitle:微小RNA与非小细胞肺癌
- Author:
Yan HE
;
Yimin LIU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
MicroRNAs
- From:
Journal of International Oncology
2012;39(4):282-285
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a class of small non-coding RNAs which involve in the regulation after gene transplantation.Researches show that miRNA is closely related to the development and progression of non-small-cell lung cancer (NSCLC).They caused a significantly change in NSCLC cells through downregulate tumor suppressor gene,or act as oncogene or work on some targets which is important in cell signal pathway,in the end it lead to oncogenesis,cell proliferation,cell apoptosis and resistance to chemotherapy or radiotherapy.Therefore,miRNA will be hopefully used in the diagnose and therapy of cancer.
