Effect of Clopidogrel on Plasma Endothelin and Calcitonin Gene Related Peptide in Patients with Unstable Angina Pectoris

VernacularTitle:氯吡格雷对不稳定型心绞痛患者血浆内皮素和降钙素基因相关肽的影响
Author: Ming ZHU ; Di LU ; Minli ZHANG ; Hongjie WEI ; Peng JIN
Publication Type:Journal Article
Keywords: Clopidogrel; Unstable angina pectoris; Endothelin; Calcitonin gene related peptide
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(5):699-700
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of Clopidogrel on the plasma endothelin(ET)and calcitonin gene related peptide(CGRP)in patients with unstable angina pectoris(UAP).Methods Patients with UAP were divided into two groups,the regular treated group(n =50)was treated with Isoket and the Dansben group(n =50)was treated with combined Isoket and Clopidogrel.The plasma ET and CGRP were measured before and after treatment by radioimmunoreactive assay.Data were compared between the two groups and also compared with those measured in 20healthy subjects for control.Results ET level was significantly higher and CGRP level was lower in UAP patients than that in healthy subjects(P ＜ 0.05).After Clopidogrel treatment,ET was significantly decreased(P ＜ 0.01)and CGRP increased(P ＜0.05)in combined treatment group compared with patients received lsoket only.Conclusion Clopidogrel was an effective drug for UAP treatment,which could efficiently regulate the ET and CGRP metabolism.