Effects of high dosage of atorvastatin in acute coronary syndrome patients on hsCRP and carotid atherosclerosis

VernacularTitle:大剂量阿托伐他汀联合替罗非班对急性冠脉综合征患者颈动脉粥样硬化的影响
Author: Yuxia QI
Publication Type:Journal Article
Keywords: Atorvastatin; Acute coronary syndrome; High sensitive C-reactive protein; Carotid atherosclerosis
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(5):703-705
CountryChina
Language:Chinese
Abstract: Objective To study effects of high dosage of atorvastatin in acute coronary syndrome(ACS)patients on high sensitive creactive protein(hsCRP)and atherosclerosis.Methods 126 cases with ACS were divided into A,B and C group.30 patients in A group were given atorvastatin 20mg per night,41 cases in B group were given atorvastatin 40mg per night,while the other 55 patients in C group were taken atorvastatin 40mg per night and tirofiban in the first 24 to 48 hours.The patients were followed 6 months by evaluating serum hsCRP concentration,measuring the intimal thickness in the carotid artery with color Doppler.Results After treatment for 6 months,the patients in the three groups showed significant decrease in hsCRP,however,the therapeutic group showed significant difference amony the three groups.Additionally,the B and C groups further showed significant decrease in intimal thickness.Conclusion Using high-dose atorvastatin and tirofiban not only lowers hsCRP significantly,but also benefit stability of atherosclerotic plaque in carotid artery,and to reduce cardiovascular events.