Research progression of tumor-associated macrophage and hepa-tocellular carcinoma
10.3760/cma.j.issn.1673-4203.2012.04.014
- VernacularTitle:肿瘤相关巨噬细胞与肝癌的研究进展
- Author:
Yongsheng GE
;
Geliang XU
;
Weifeng LIU
- Publication Type:Journal Article
- Keywords:
Macrophage;
Tumor microenvironment;
Liver neoplasms
- From:
International Journal of Surgery
2012;39(4):260-263
- CountryChina
- Language:Chinese
-
Abstract:
Chronic inflammation has been demonstrated closely related to the tumor progression.Tumorassociated macrophage,as the most abundant immune cells in the tumor microenvironment,is a key element that links inflammation and cancer.Recently,studies found that the phenomenon and function of tumor-associated macrophage almost tend to M2 type macrophage.As an important indicator,tumor-associated macrophage usually predicts the poor progress with the cancer development.In China,Most of patients with hepatocellular carcinoma are associated with chronic viral infection.A large number of macrophages in the liver infiltrated in chronic inflammation,which are differentiated by variety of mechanisms under the chronic inflammatory stimulation,promote the development of liver cancer.In this paper,we will review the tumor-associated macrophages and the development of liver cancer.
