Influence of bevacizumab on the invasion of glioma and the mechanism

VernacularTitle:贝伐单抗对胶质瘤侵袭性的影响及其机制
Author: Liming DAI ; Zhiqiang LI
Publication Type:Journal Article
Keywords: Glioblastoma; Invasion; Anoxi; Bevacizumab
From: Journal of International Oncology 2012;39(4):259-261
CountryChina
Language:Chinese
Abstract: Angiogenesis and invasion are two remarkable features of spongioblastoma,which lead to the failure of clinical treatment.With the development of the glioma（s） molecular biology mechanism in the realm of angiogenesis,some anti-angiogenesis drugs have got a positive therapeutic efficacy in the clinical trials,such as bevacizumab.However,it is reported that these drugs maybe also enhance the invasion and migration ability of glioma cells in the process of anti-angiogenesis therapy.Matrix metalloproteinases,hypoxia induced factor-1 and the inositol-requiring enzyme-1 maybe have some correlations with the change of the invasion and migration,but the molecular biological mechanism needs further research.