Meta-analysis for the curative effects of simvastatin combined with low molecular weight heparin in patient with unstable angina

VernacularTitle:辛伐他汀联合低分子肝素治疗不稳定型心绞痛效果的Meta分析
Author: Bingzhong CHEN ; Wei WANG
Publication Type:Journal Article
Keywords: Simvastatin; Low molecular weight heparin; Unstable angina; Meta Analysis
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):505-506
CountryChina
Language:Chinese
Abstract: Objective To assess the curative effects of simvastatin combine with low molecular weight heparin in patient with unstable angina.Methods The papers from China Academic Journal ( CNKI),Chongqing VIP (VIP),PubMed database were retrieved by computer,15 randomized controlled trials( 1206 patients) were included for Meta-analysis.ResultsThe overall efficiency of the two groups were compared by Fixed effects model:x2 =2.62,Consolidated RR =1.30 (95％ CI:1.23 ～ 1.38 ) ; the number of attacks after treatment of the two groups were compared by random effects model:x2 =1231.87,WMD =- 2.68 ( - 5.82,0.5 ) ; the duration time of attacks after treatment in both groups were compared by random effects model:x2 =1231.87,weighted mean difference =-2.68(-5.82,0.5).Conclusion Simvastatin combine with low molecular weight heparin could improve the overall efficiency on patient with unstable angina,and could not reduce the number of attacks after treatment,but could reduce the duration time of attacks after the treatment.