Correlation study on angiotensin Ⅱ type 2 receptor gene single nucleotide polymorphisms in essential and renal hypertension

VernacularTitle:原发性高血压和肾性高血压患者血管紧张素Ⅱ2型受体基因单核苷酸多态性的相关性研究
Author: Gangqiang LI ; Rui ZHU ; Wei YAN ; Shengwu CHAO
Publication Type:Journal Article
Keywords: Essential hypertension; Renal hypertension; Angiotensin Ⅱ; Receptor; Single nucleotide polymorphism
From: Clinical Medicine of China 2012;28(4):351-353
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between angiotensin Ⅱ type 2 receptor (AGTR2) gene single nucleotide polymorphisms and hypertension in patients with essential hypertension and renal hypertension.Methods Direct DNA sequencing was performed to detect the single nucleotide polymorphisms (SNP) in eighty patients with essential hypertension,eighty patients with renal hypertension and forty normal blood pressure controls.Results There was significant difference on A allele frequencies between essential hypertension group and control group ( 56.88％ [ 91/160 ] vs 30.00％ [ 24/80 ],x2 =15.44,P ＜ 0.001 ).A allele frequency had no correlation with renal hypertension (42.50％ [ 68/160 ] vs 30.00％ [ 24/80 ],x2 =3.52,P ＞0.05).There was no significant difference on SNP between essential hypertension group and renal hypertension group ( P ＞ 0.05 ).Conclusion A1675G signal nucleotide polymorphisms of AGTR2 may be associated with the development of essential hypertension,but has nothing to do with renal hypertension.