Research for early growth response gene-1 in ischemia-reperfusion injury
10.3760/cma.j.issn.1673-4203.2012.04.016
- VernacularTitle:早期生长反应基因-1在缺血再灌注损伤中的研究进展
- Author:
Jianhu GAO
;
Qiping LU
- Publication Type:Journal Article
- Keywords:
Early growth response gene-1;
Ischemia-reperfusion injury;
Transcription factor
- From:
International Journal of Surgery
2012;39(4):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Early growth response gene-1 is an immediate early response gene,a transcription factor which includ three zinc finger-like domains.Recentl studies demonstrate that early growth response gene-1 is involved in regulating cell cycle,proliferation and differentiation,and plays a critical role in injuring and repairing.Early growth response gene- 1 induces Target genes,and promotes extracellular environmental signal( such as oxygen deficit,oxidative stress,mechanical injury and cytokine)link with the complex biological responses.Intensive study to early growth respnse gene-1 will contribute to further illustrate the mechanism of the ischemia-reperfusion injury.This article summarizes from protein structure,signal transduction,biological functions and the relationship with ischemia- reperfusion injury.
