Ku proteins and tumor radiosensitivity

VernacularTitle:Ku蛋白与肿瘤放射敏感性
Author: Tianqian LI ; Shuhui YU ; Guomiao LI ; Wenhui LI
Publication Type:Journal Article
Keywords: Neoplasms; Radiation tolerance; Ku proteins
From: Journal of International Oncology 2012;39(4):249-251
CountryChina
Language:Chinese
Abstract: Ku is a heterodimeric protein which is composed of Ku70 and Ku80.DNA dependent protein kinase is composed of Ku and DNA dependent protein kinase catalytic subunit (DNA-PKcs).DNA double strands break is the main method that radiation kill tumor cell,which will restraint DNA repair,and induce cell apoptosis.Ku protein is the key point in the repair of DNA.Blocking Ku protein will increase the radiosensitivity of tumor cell.