Polyinosinic-polycytidylic acid and tumor immunity
10.3760/cma.j.issn.1673-422X.2012.04.004
- VernacularTitle:聚肌胞与肿瘤免疫
- Author:
Yusheng CHENG
;
Jingyan XIA
;
Feng XU
- Publication Type:Journal Article
- Keywords:
Poly I-C;
Immunity;
Neoplasms
- From:
Journal of International Oncology
2012;39(4):252-254
- CountryChina
- Language:Chinese
-
Abstract:
Polyinosinic-polycytidylic acid is a synthetic analog of double-stranded RNA,which plays a vital role in the regulation of immune system.Toll-like receptor 3 ( TLR3 ),melanoma differentiation-associated gene 5 (MAD-5) and retinoic acid inducible gene - Ⅰ ( RIG- Ⅰ ) are the main three intracellular receptors binding to polyinosinic-polycytidylic acid which activates human anti-tumor immune responses including the activation of innate immunity and acquired immunity through TIR-domain-containing adapter-inducing inter feron-β (TRIF) and interferon-β.Thus,polyinosinic-polycytidylic acid plays an important role in regulating anti-tumor immune responses.The immunoregulation mechanisms ofpolyinosinic-polycytidylic acid in melanoma,breast cancer,malignant glioma and lung cancer have been clarified,which will provide new strategies for tumor immunotherapy.
