Expression of TAP1 and TNF-α in HBV-related hepatocellular carcinoma and its clinical significance
10.3760/cma.j.issn.1008-6706.2012.05.002
- VernacularTitle:HBV相关肝癌组织中TAP1及TNF-α的表达及意义
- Author:
Bing QIU
;
Xi WANG
;
Bo HUANG
;
Wenduo WANG
;
Qinghua LI
;
Dongfu LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatocellular carcinoma;
Expression
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(5):643-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of expression of transporter associated with antigen processing(TAP1),tumor necrosis factor-alpha(TNF-α)with occurrence and development of HBV-related hepatocellular carcinoma(HCC).Methods The expression of TAP1 and TNF-α in 35 liver carcinoma tissues,and 10 normal liver tissues were detected with immunohistochemical EnVision method,The expression and clinical significance of TAP1,TNF-α in HBV-related HCC were analyzed.Furthermore,the association of respective expression quantity with pathological typing of HCC was analyzed.Results The expression of TAP1,TNF-α was negative in hepatocytes of normal liver tissues.91.4％ of HCC tissues expressed TAP1.There was significantly statistical difference in expression of TAP1 between HCC tissues and the normal hepatic tissues(P ＜ 0.05);60％ of HCC tissues expressed TNF-α.There was statistical difference in expression of TNF-α between HCC and the normal hepatic tissues(P ＜ 0.05),and the positive expression rate of TNF-α in well-differenciated HCC tissues was significantly higher than that in poorly-differenciated ones(P ＜ 0.05).Conclusion TAP1-related MHC-Ⅰ restricted antigen processing pathway was possibly normal in HBV-related HCC.The expression quantity of TNF-α was associated with the occurrence and degree of pathological differentiation of HBV-related HCC.
