Gene mutations and the phenotype of BCR/ABL-negative myeloproliferative neoplasms
10.3760/cma.j.issn.1673-422X.2012.04.021
- VernacularTitle:基因突变与骨髓增殖性肿瘤表型的相关性
- Author:
Xiu FENG
;
Jian OUYANG
;
Min ZHOU
- Publication Type:Journal Article
- Keywords:
Genes;
Mutation;
Myeloproliferative disorders;
Phenotype
- From:
Journal of International Oncology
2012;39(4):307-310
- CountryChina
- Language:Chinese
-
Abstract:
Janus kinase 2,myeloproliferative leukemia virus and tet encogene family member2 mutations affect a variety of cytokines signal transduction pathway in BCR/ABL-negative myeloproliferative neoplasms (MPN). In the influence of mutation load,co-mutation and genetic susceptibility,these mutations can induce different MPN phenotypes,and affect the characteristics of patients,the distribution of peripheral blood cells and prognosis. But how these mutations contribute to disease initiation,development,and transformation needs further reseach.
