Clinical study on the effect of the high-dose leucovorin plus fluorouracil in combination with cisplatin in the treatment of advanced esophageal cancer
10.3760/cma.j.issn.1008-6706.2012.05.008
- VernacularTitle:大剂量醛氢叶酸加氟尿嘧啶持续滴注联合顺铂治疗晚期食管癌临床研究
- Author:
Lei CHEN
;
Qini XU
;
Jin ZHENG
- Publication Type:Journal Article
- Keywords:
LV;
5-Fu;
DDP;
Esophageal cancer,chemotherapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(5):659-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of high-dose leucovorin(LV)plus 5-fluorouracil(5-Fu)for 48hours infusion in combination with cisplatin(DDP)in treatment of advanced esophageal cancer.Methods Pathological diagnosis of esophageal cancer 60 cases were randomly divided into treatment group of 30 patients,using DDP 25mg/m2 intravenous infusion 30 minutes,d1～3,LV 200mg/m2 intravenous infusion 2 hours,5-Fu 0.5 intravenous injection 10 minutes,and 5-Fu 2.5/m2,continuous infusion with the infusion pump for 48 hours every 21 days,2 cycles of assessment of efficacy.Control group of 30 patients,using DDP 25mg/m2 intravenous infusion 30 minutes,d1～3,LV 60mg/m2 intravenously two hours,d1～5,5-Fu 500mg/m2 intravenously 8 hours every 21 days,2 cycles of assessment of efficacy.Results Short-term effect,treatment group,complete remission(CR)1 patient and partial remission(PR)15 cases,stable(SD)9 cases,progress(PD)5 cases,the total effective rate of CR + PR53.3％(16/30).Control group,PR 11 patients,SD 11 cases,PD 8 cases,no cases of PR,the total effective rate 36.7 ％(11/30).Nausea,vomiting,oral mucositis,bone marrow suppression,diarrhea and hair loss were the main adverse reactions.Two groups are able to withstand,without any Ⅳ toxicities,myelosuppression was significant in control group than the treatment group.Conclusion High-dose LV + 5-Fu 48 hours infusion combined platinum-term efficacy in treatment of advanced esophageal cancer compared with conventional DF program is good,less adverse reactions,should further expand the study.
