Effect of alprostadil on recovery of renal transplant recipients with delayed graft function
10.3760/cma.j.issn.1008-6706.2012.05.013
- VernacularTitle:移植肾功能延迟恢复患者早期应用前列地尔临床观察
- Author:
Bangqi WANG
;
Yunsong ZHU
;
Haibo NIE
;
Yongbin ZHAO
;
Liang TONG
;
Weilie HU
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Delayed graft function;
Alprostadil
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(5):669-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of alprostadil on accelerating early recovery of renal transplant patients with delayed graft function.Methods A randomized control clinical trial was designed in renal recipients with delayed graft function(DGF)who were administered with 50μg alprostadil each day after the operation.The effects of alprostadil were compared with the control group which included 14 recipients with DGF to determine the influences of alprostadil on urine,serum creatinine(SCr).Under Doppler ultrasound,the renal blood flow resistance-indexes(RI)were measured.The rates of acute renal graft rejection(AR)were also calculated in both groups,and the 1year patient/graft survival rates were compared between the two groups.Results Urine was significantly higher in alprostadil-treated group than in control group(P ＜ 0.05).On the contrary,SCr and RI were significantly lower in alprostadil-treated group than in control group(P ＜ 0.05).No significant differences were found between the two groups in AR rate(6.25％ vs 7.14％)and the 1-year patient/graft survival rates(P ＞ 0.05).Conclusion The application of alprostadil in renal recipients with DGF had beneficial effects on accelerating recovery of renal graft function.
