Variations of biomarkers in gastrointestinal stromal tumor and prognoses of the patients and targeted drug sensitivity
10.3760/cma.j.issn.1673-422X.2012.04.017
- VernacularTitle:胃肠间质瘤生物标志物改变与患者预后及靶向药物疗效的关系
- Author:
Wen SUN
;
Jinfei CHEN
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Biological markers;
Prognosis;
Molecular targeted therapy
- From:
Journal of International Oncology
2012;39(4):295-298
- CountryChina
- Language:Chinese
-
Abstract:
Many researches show that the prognosis of gastrointestinal stromal tumor (GIST) are relatedtonumerousvariationsofbiomarkerssuchasnumericchromosomalaberrationsor nuclear/mitochondrialmicrosatelliteinstability.Inaddition, thechangesofproto-oncogeneand tumor-suppressor gene are found to influence the prognosis of GIST.The kit and platelet-derived growth factor receptor gene mutation are correlated with GIST progression,metastasis and targeted drug sensitivity,and then influence the prognosis of GIST.
