The clinical significance of testing plasma brain natriuretic peptide(BNP) in cardioembolic stroke patients

VernacularTitle:心源性脑卒中患者血浆脑钠肽水平测定及其临床意义
Author: Yonghong LI ; Peng WANG ; Xu ZHAO
Publication Type:Journal Article
Keywords: Cardioembolic stroke; Bain natriuretic peptide
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):493-494
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between cardioembolic stroke and plasma BNP by analyzing the plasma BNP level in cardioembolic stroke patients.Methods The clinical data of 81 patients with acute stroke were collected.According to the TOAST classification,all the patients were diagnosed as non-cardioembolic stroke,including atherothrombotic,lacunar,others etiology and undetermined etiology cardioembolic stroke.Blood samples were drawn on emergency department arrival( within 24 hours) to test BNP( assayed by ELISA).The plasma BNP level between non-cardioembolic stroke and cardioembolic stroke was compared.Results Cardiogenic stroke patients with plasma BNP level( 147.5 ±7.8 ) ng/L,atherosclerotic stroke patients level(51.2 ± 5.8) ng/L,lacunar stroke( 39.5 ±10.0)ng/L.Higher levels of BNP were observed in patients with cardioembolic stroke than other stroke subtypes(t =67.8,23.6,17.6,all P ＜ 0.01 ).Conclusion The plasma BNP could be used for distinguishing cardioembolic stroke from other stroke subtypes and has great clinical significance in etiologic diagnosis of ischemic stroke subtypes.