Clinical effect of GnRH-α in treatment of patients with endometriosis after laparoscope surgery

VernacularTitle:腹腔镜术后联合应用促性腺素释放激素类似物治疗子宫内膜异位症的疗效观察
Author: Zhujuan HUANG ; Yeping WEI ; Yan HUANG
Publication Type:Journal Article
Keywords: Laparoscope; GnRH-α; Endometriosis
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):495-496
CountryChina
Language:Chinese
Abstract: Objective To study the clinical effect of GnRH-α in treatment of patients with endometriosis after laparoscope surgery.Methods 185 endometriosis patients who got laparoscope surgery were randomly divided into the observation group(93 cases) and the control group(92 cases),and took GnRH-α and gastrinone,respectively.After 24 months follow-up,the outcomes of pelvic cavity symptom improvement,recurrence and pregnancy were observed.Results After treatment,the pelvic cavity symptom improvement (87.1％ ) and pregnancy rate (79.3 ％ ) in the observation group was higher than those of the control group(70.7％,52.4％ ) (x2 =7.517,4.059,all P ＜0.05),and the recurrence rate( 19.4％ ) in the observation group was lower than that of the control group(34.8％ )(x2 =5.581,P ＜0.05).Conclusion The treatment of endometriosis with GnRH-α combined with laparoscope surgery could attain desirable effect.Compared with gastrinone,it could effectively improve pelvic cavity symptom,decrease recurrence and increase the rate of pregnancy.