Expression and clinical significance of gonadotropin-releasing hormone receptor and epidermal growth factor receptor in gastric carcinoma

VernacularTitle:促性激素释放激素受体与表皮生长因子受体在胃癌组织中的表达及意义
Author: Yuedong PAN ; Mingzhu LU ; Meizhen WAN
Publication Type:Journal Article
Keywords: Stomach neoplasms; Receptors; Gonadotropin-releasing hormone
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):524-526
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions of gonadotropin-releasing hormone receptor(GnRHR)and epidermal growth factor receptor(EGFR) in gastric carcinoma and to explore its clinical significance.Methods The expressions of GnRHR and EGFR in 31 cases of gastric carcinoma were observed by SP immunohistochemical method and the method of in situ quantification.Results The GnRHR and EGFR positive immunoreactive substances were located in the tumor cells of gastric carcinoma,GnRHR 28 cases (90.32％ ),EGFR 15 cases ( 48.39％ ),the expression of GnRHR increased in accordance with histologic differentiation,well-differentiated 14 cases,moderately differentiated 9 cases,poorly differentiated 5 cases,the expression of EGFR decreased in accordance with its increasing degree of histologic differentiation,well-differentiated 3 cases,moderately differentiated 5 cases,poorly differentiated 7 cases,( P ＜ 0.05 ),and GnRHR was more obvious than EGFR in immunoreaction.Conclusion GnRHR and EGFR could be related to the pathogenesis and the development of the gastric carcinoma.