Observation on the effect of docetaxel,cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer

VernacularTitle:多西他赛、顺铂联合同期放疗治疗中晚期宫颈癌的疗效观察
Author: Yinmou GUO
Publication Type:Journal Article
Keywords: Cervical cancer; Chemotherapy; Radiotherapy; Docetaxel; Cisplatin
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):503-504
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of docetaxel,cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer.Methods 64 patients with advanced cervical cancer were randomly divided into two groups,observation group with 32 cases who were treated with docetaxel and cisplatin concurrent chemotherapy and radiotherapy and control group with 32 cases were treated with radiotherapy.The clinical effect and adverse reaction between two groups were compared.Results The total effective rate in observation group was 84.4％,which significantly higher than that in control group of 59.4％ ( x2 =4.07,P ＜0.05 ).There were no significant differences in incidences of bone marrow suppression and nausea and vomiting between two groups(x2 =1.09,1.17,all P ＞0.05).Conclusion Docetaxel,cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer could enhance clinical effect,and not increase the adverse reaction incidence,which could be applied in clinic.